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EFFICACY REPORT 

 EFFICACY REPORT ON DETRILUMINO® - ACTIVE INGREDIENT

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STRICTLY PRIVATE & CONFIDENTIAL

 

​ALCOHOL COUNTER ACTOR

ON YOUR FEET AGAIN!

The information contained herein is to be considered commercially confidential and sensitive and is covered by a related confidentiality agreement, or professional secrecy. This document is not to be copied or reproduced in any way, in part or in whole, without the express written consent of ANDRIE HANCKE.

TITLE  

          

To determine if the Active Ingredient is effective in increasing the elimination of alcohol in humans.

 

AIM 

                   

To assess the influence of the Active Ingredient on breath alcohol levels.

 

HYPOTHESIS

The Active Ingredient does significantly decrease blood alcohol levels and therefore breath alcohol levels.

 

​METHOD

           

A manager of a local pub secured 21 volunteers for this project.  Subjects were 17 males and 4 females who were frequent visitors to the pub, i.e., people well used to alcohol and not novices. All were over 21 years of age.

 

The volunteer’s age, mass and past drinking habits were noted.  They were isolated in a large area, away from the other patrons, where they could drink alcohol as they normally would and at a rate that was usual/normal for them. This would allow adequate time for absorption.  Meals were eaten during the period of drinking.

 

The type and amount of alcohol consumed was documented. Individuals were told to stop drinking once they had consumed the amount of alcohol they normally would have.  Thereafter a 15 to 20-minute waiting period followed, wherein no alcohol or smoking was allowed.  The first breath alcohol level was then recorded. 

 

This was immediately followed by administering either 5g or 10g the Active Ingredient. This was administered orally, either in 1g tablet of the Active Ingredient or powder mixed in a liquid form.  This liquid comprised of water, the Active Ingredient powder, sucrose, citric acid, flavourant, colourant, stabilizer and preservative.

 

A further waiting period of approximately 30 minutes followed.  During this period no alcohol was consumed.  Over the latter part of this thirty-minute period no smoking was allowed.  Thereafter the second breath alcohol level was recorded and the rate of elimination for that period was recorded.

 

A period of six days passed allowing a ‘flush-out’ of the Active Ingredient from the bowel.  The subjects were then assessed at the same venue, consumed, as far as possible, the same amount and type of alcohol at similar rates and had the same meal.  Breath measurements were performed as for the Active Ingredient but a placebo was administered. 

 

Placebo was made into a liquid beverage similar to that of the Active Ingredient but raw maize starch grounds were substituted for the Active Ingredient and the rest of the ingredients remained unchanged.  Once again, the rate of elimination of alcohol was calculated.

Finally, the rate of elimination of breath alcohol when taking the Active Ingredient was compared to the rate of elimination when using placebo.

 

RESULTS  

        

Of the 21 volunteers tested with the Active Ingredient, in one individual a reading was not obtained due to an interferant (and was subsequently dropped from the study); four volunteers did not return for second testing and the remaining sixteen were further tested with the placebo.

 

See attached table for the results on pages 22 and 23.       

 

The results in the table indicate that 14 of the 16 volunteers demonstrated an increased rate of elimination using the Active Ingredient.  The range of increased elimination of alcohol varied from 0.006mg/1000mls of air to 0.469mg/1000mls of air, with the average being 0.070mg/1000mls of air.

                                   

DISCUSSION

In this study breath levels rather than blood levels were used to monitor alcohol levels.  This was the preferred means of measuring the alcohol since obtaining blood levels is invasive. Furthermore, the instrument used was the Drager 7110 which is extremely accurate and at all material times reflects the blood alcohol level. The Active Ingredient is volcanic rock crushed to particles measuring an average of 10 microns. It is likely that the Active Ingredient adsorbs the alcohol in the lumen of the gut and possibly also adsorbs alcohol from the mucosal capillaries of the small bowel.

Since the early 1960’s when legislation made provision for a maximum permissible blood alcohol level (and more recently a breath alcohol level), scientists have looked at various ways in which to increase the rate of elimination of alcohol from the body. The human body eliminates alcohol primarily through metabolism in the liver and this occurs at an average rate of 0.015g/100mls of blood or 0.072mg /1000mls of air, per hour. 

 

Until now, the only way to increase alcohol elimination was the use of fructose, a type of sugar.  Fructose had to be administered intravenously and it has uncomfortable side effects and therefore is considered to be impractical to use.

There is continued research to find a product that could firstly, work efficiently and secondly, be practical to se. This study showed the Active Ingredient increased elimination of alcohol in 14 of 16 subjects and it was very easy to administer via tablets or a liquid beverage. 

 

The reason for administering the Active Ingredient at the end of the drinking period is that people, after having their quota of alcohol, could take the Active Ingredient, wait approximately thirty minutes for alcohol levels to drop, before driving their vehicles. From a medico-legal viewpoint, using the Active Ingredients not considered a means of cheating the breathalyzer, since it first lowers the blood alcohol level which reflects on the breath alcohol levels.

CONCLUSION

  

The Active Ingredient has been shown to be the only product that can be taken orally and reduce alcohol levels in the body. Furthermore, it is a practical product in that it can be taken in tablet or liquid form, and the individual waits for thirty minutes for the Active Ingredient to work and then drive with a lower alcohol level. The reduced alcohol levels will result in decreased levels of intoxication and will accordingly impact in decreasing motor vehicle collisions.

 

Done by: Specialist Forensic Pathologist/Senior Lecturer

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